Fifty eight patients with osteoarthritis (OA) were randomized to receive arthroscopic treatment with or without intra-operative leukocyte-poor platelet-rich plasma (LP-PRP) injection. The goal of this study was to determine if there were any benefits to the added PRP intervention in terms of pain, function, or quality of life. The primary outcome of interest was pain as measured at 6 months after surgery. Results demonstrated lower pain at 6 months for patients receiving LP-PRP, as well as significantly higher scores on function and quality-of-life measures up to one year after surgery, as compared to patients who underwent arthroscopy alone.