A total of 22 randomized controlled trials were included in the meta-analysis investigating the effect of hyaluronic acid on pain in the treatment of knee osteoarthritis. Data was sampled from a total of 2949 patients across all trials. The results demonstrated a small, but significant, effect size when intra-articular hyaluronic acid was compared to placebo for pain severity. An analysis of only studies which featured a low-molecular-weight hyaluronic acid product demonstrated an even smaller, but still statistically significant, effect size. Publication bias was detected, and the clinical relevance of the findings and effect sizes was unknown.