Osteoarthritis
Intra-articular hyaluronate improves pain and joint narrowing in knee osteoarthritis
. 1993 ;():.
209 patients, between April and October 1990, with idiopathic knee osteoarthritis, were randomized to receive intra-articular injections of either 25mg/2.5mL sodium hyaluronate as active treatment or 0.25mg/2.5mL sodium hyaluronate as a control. The purpose of this study was to compare changes in pain, knee joint narrowing, joint mobility and joint effusion to determine if hyaluronate was an effective treatment of osteoarthritis. Results indicate that the active treatment group showed significant improvements in pain and knee joint narrowing, but not for any of the other studied parameters.
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