60 patients presenting with humeral shaft fractures were randomized to undergo surgical fixation with either an intramedullary interlocking nail or locking compression plate. The purpose of the study was to compare operational and functional outcomes of these fixation methods over 1 year postoperatively. The results showed that intramedullary nail led to significantly shorter operative times, hospital stay, lower intraoperative blood loss, and earlier fracture union. The groups were comparable in terms of functional outcomes and the incidence of non-union.