SPINE
Results from randomized controlled trials in spine surgery frequently fragile
This report has been verified
by one or more authors of the
original publication.
Spine J. 2015 Oct 1;15(10):2188-97
Results from 40 randomized controlled trials investigating interventions in spine surgery were included in this study. This review aimed to apply the recently described Fragility Index to statistically significant dichotomous outcomes in order to examine the robustness of these results. The median Fragility Index was 2 (IQR 1-3), indicating that the changing of a non-event into an event in only a few patients would cause statistical significance to be lost in a number of cases.
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