OSTEOARTHRITIS
Network meta-analysis of glucosamine and/or chondroitin, celecoxib, and placebo in knee OA
Sci Rep. 2015 Nov 18;5:16827A total of 54 studies were selected for inclusion in a network meta-analysis comparing the effects of celecoxib, glucosamine, chondroitin, glucosamine + chondroitin, and placebo on pain and functional outcome in patients with knee osteoarthritis. Regarding pain, all four treatment groups (celecoxib, glucosamine, chondroitin, glucosamine + chondroitin) demonstrated a significant positive effect on pain relief relative to placebo. Regarding function, three of the treatment groups - celecoxib, glucosamine, and glucosamine + chondroitin, demonstrated a significant positive effect relative to placebo, while chondroitin, alone, did not. Data was pooled based on last time-point available, resulting in the inability to determine the duration of effect regarding the current findings.
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