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OSTEOARTHRITIS
No clinically important effects of hyaluronic acid injection in knee osteoarthritis
Verified
This report has been verified by one or more authors of the original publication.
J Bone Joint Surg Am. 2015 Dec 16;97(24):2047-60
Contributing Authors

D Jevsevar P Donnelly GA Brown DS Cummins

19 randomized controlled trials (4485 patients) analyzing the effects of hyaluronic acid injection on pain, function and stiffness in knee osteoarthritis patients were included. The purpose of this meta-analysis was to determine the clinical significance of hyaluronic acid and which trial factors influence the treatment effects on pain, function, and stiffness. The results displayed that double-blinded, sham-controlled trials displayed smaller treatment effects than trials that were not sufficiently blinded and cross-linked hyaluronic acid displayed better treatment effects than non-cross-linked preparations. The overall treatment effect of hyaluronic acid was determined to be non-clinically important in pain function and stiffness in these 19 studies.

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Cite this Ace Report

OrthoEvidence. No clinically important effects of hyaluronic acid injection in knee osteoarthritis. ACE Report. 2016;6(1):61. Available from: https://myorthoevidence.com/AceReport/Report/

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