100 patients with knee osteoarthritis who were ineligible for total knee replacement were randomized to undergo treatment with either a 3-month program consisting of neuromuscular exercise, education, diet, insoles, and pain medication (the MEDIC-treatment), or usual care. Although it was determined in a prior study that the MEDIC-treatment was able to improve pain outcomes, the present study was conducted to investigate its efficacy specific to pain sensitization, at program completion. The findings of this report indicated that while improvements were seen in the non-surgical group in other additional pain outcomes, sensitization was comparable between groups.