58 patients with low back pain due to degenerative lumbar disease were randomized to intradiscal injection of 1-2mL of either platelet-rich plasma (PRP) or contrast agent (Omnipaque 180). The purpose of this study was to evaluate the efficacy of PRP for improvement of measures of pain and function relative to a nonactive injection. Follow-up was performed over 8 weeks post-injection. Results after 8 weeks were mixed; significant differences in favor of PRP injection versus control were observed for the Functional Rating Index (FRI) and Numeric Rating Scale (NRS) of best pain, although no significant between-group differences were observed for NRS current pain and worst pain, or Physical Function and Pain dimensions of the SF-36.