63 patients undergoing anterior cruciate ligament reconstruction (ACLR) (using ipsilateral quadrupled semitendinosus graft) were randomized to three groups. Group I received 0.25% bupivacaine infused intra-articularly (intervention), Group II received 0.9% saline infused intra-articularly (placebo) and Group III received no intra-articular infusion catheter (control). Results showed that there were no statistically significant differences between the three groups in the outcomes of visual analogue scale (VAS) pain scores and analgesic use over the course of the entire study at the 96-hour follow-up.