80 patients undergoing arthroscopic rotator cuff repair with concomitant biceps tenodesis were randomized to either interference screw (IS) fixation or suture anchor (SA) fixation. The purpose of this study was to compare the clinical and anatomical outcomes between fixation methods for at least 12 month follow-up. Findings indicated that VAS pain, ASES form, Simple Shoulder Test, Constant score, and Long Head Biceps scores were all comparable between the two groups. Anatomical tenodesis failure was determined to be significantly higher in the IS group compared to the AS group, as well as in patients with higher work level.