9 randomized controlled trials which compared autologous whole blood (ABI) injections to either corticosteroid injections (CSI) (6 RCTs) or platelet-rich plasma injections (PRP) (3 RCTs) in the treatment of lateral epicondylitis were included in the current meta-analysis. Comparisons were performed to assess the effect of these treatment options on pain. Pooled results demonstrated a significant effect in favour of ABI versus CSI, and a non-significant effect between ABI and PRP. Sensitivity analysis, which excluded trials with high-risk of bias, demonstrated a non-significant difference between ABI and CSI, while results were maintained in the analysis of ABI versus PRP.