5 randomized controlled trials (RCTs) were included in this systematic review to analyze outcomes of pulsed radiofrequency (PRF) treatment in patients with shoulder pain. Findings of this study indicated that the use of PRF demonstrated marked within-group improvement of passive range of motion (PROM), visual analogue scale (VAS) pain scores, and Shoulder Pain and Disability Index (SPADI) from baseline to 12 weeks follow-up. However, when compared to various control interventions, results on the efficacy of PRF were mixed based on the based on the type of control intervention (intra-articular corticosteroids, transcutaneous electrical nerve stimulation, physical therapy) being compared to.