14 randomized controlled trials were included in this meta-analysis comparing postoperative analgesia following total knee arthroplasty between local infiltration analgesia (LIA) and peripheral nerve block (PNB). Pooled outcomes included postoperative morphine consumption, postoperative pain scores at rest and on movement, knee range of motion, Knee Society Score, and complications/adverse events. Results were pooled for data up to three days postoperatively. Significant differences that were found between groups included lower morphine consumption at 12 hours postoperatively in LIA cohorts, as well as significantly lower knee range of motion at 2 days postoperatively in LIA cohorts. Otherwise, all pooled analyses yielded non-significant differences between LIA and PNB groups.