99 patients with lumbar facet joint syndrome were randomized to one of three study groups for the purpose of comparing the efficacy of pain and disability relief throughout a 12-week observational period: (1) combination of methylprednisolone injection and oral diclofenac, (2) methylprednisolone injection alone, or (3) oral diclofenac alone. Results demonstrated that in general, combination therapy provided the greatest significant reduction in VAS pain and ODI disability scores on the short-term, followed by methylprednisolone injection and diclofenac respectively.