OSTEOARTHRITIS
Short-term pain and function benefit with HA for knee OA in trials with low risk of bias
RMD Open. 2015 May 14;1(1):e000071Eight double-blind, placebo controlled randomized trials were included in this meta-analysis assessing efficacy outcomes of intra-articular hyaluronic acid injections in the treatment of knee osteoarthritis. Data on pain and functional outcome measures were extracted and pooled. Results demonstrated small but statistically significant differences between IAHA and IA placebo injections in both pain and functional outcome at 3 months. GRADE assessment indicated "moderate" quality of evidence related to both outcomes.
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