6 randomized clinical trials were included in this meta-analysis to evaluate the comparative efficacy of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the management of knee osteoarthritis. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate outcome. The results of this meta-analysis demonstrated low-quality evidence that PRP provided favourable results in comparison to HA for patients with knee osteoarthritis (SMD -0.75 [95%CI -1.33 to -0.18]; p=0.010; I^2=93%). Nevertheless, it is unknown if this difference is clinically relevant.