Fifteen randomized controlled trials were included in this meta-analysis and systematic reviewing comparing the efficacy and safety of autologous blood transfusion systems to both closed suction drainage and no drain use. Results on allogenic blood transfusion rate demonstrated a significantly lower rate with the use of autologous blood transfusion systems compared to closed suction drainage, but not when compared to no drain use. Hemoglobin level, the length of stay, and wound infection rate were not significantly different between either the use of autologous blood transfusion systems and closed suction drainage, or autologous blood transfusion systems and no drainage.