130 patients with an infected traumatic or surgical wound were randomized following debridement to management with either mupirocin in collagen granules and metronidazole (Co-Mupimet) or Edinburgh University Solution of Lime (EUSOL). Groups were compared for wound healing outcomes over 4-week follow-up. A significant difference in the rate of grading granulation tissue as "healthy" was reported for the Co-Mupimet group compared to the EUSOL group over the first 3 weeks of follow-up. No significant differences were reported between groups for the rate of patients demonstrating wound discharge at 1, 2, 3, or 4 weeks.