Ten studies, including nine randomized controlled trials and one prospective cohort study, were included in this meta-analysis to investigate the efficacy of injury prevention programs in adolescent team sports. Pooled results demonstrated a significant injury rate reduction with the use of injury prevention programs versus control interventions overall. Subgroup differences were noted for the type of sport, in which basketball/handball experienced a greater injury rate reduction with injury prevention programs than in soccer, and type of program implemented. NonFIFA11+ programs experienced a larger injury reduction rate than FIFA11+ programs.