
Osteoarthritis
Vitamin D does not improve radiological or clinical outcomes for patients with knee OA
Osteoarthritis Cartilage. 2016 Nov;24(11):1858-1866474 patients with Kellgren-Lawrence grade II-III knee osteoarthritis were included in a 3-year, double-blind, RCT to evaluate the effect of vitamin D supplementation on the rate of radiographic disease progression. Compared to a placebo group, patients treated with vitamin D supplementation did not demonstrate a slower rate of joint space narrowing (JSN) on radiographs over the 3-year follow-up. There were also no significant differences between groups in pain, stiffness, or function.
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