METABOLIC DISORDERS
Zoledronic Acid, alendronate, and risedronate reduce vertebral, nonvertebral, and hip fracture
This report has been verified
by one or more authors of the
original publication.
Osteoporos Int. 2016 Nov;27(11):3289-3300
36 randomized controlled trials were included in this network meta-analysis to evaluate the comparative efficacy of different bisphosphonates in the management of osteoporosis. Nine different bisphosphonates were assessed in the included studies, with direct and indirect comparisons evaluated for vertebral fracture, nonvertebral fracture, hip fracture, wrist fracture, and any fracture. Zoledronic acid seemed to be the most effective bisphosphonate for reducing the risk of fracture for vertebral fracture, nonvertebral fracture, and any fracture. While zoledronic acid or alendronate seemed to be the most effective for preventing hip fracture.
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