
Foot & Ankle
Network meta-analysis evaluating injection treatments for plantar fasciopathy
Br J Sports Med. 2016 Nov;50(22):1367-1375. doi: 10.1136/bjsports-2015-095437. Epub 2016 May 3.22 randomized controlled trials were included in this network meta-analysis, that included over 10 injectable treatments, to evaluate comparative efficacy for the management of plantar faciopathy. The primary outcome of this study was pain relief. At 0-2 month follow-up, micronized dehydrated human amniotic/chorionic membrane was the most likely treatment to be effective for pain relief. At 2-6 months, botulinum toxin A was the treatment most likely to be effective for pain relief, while a treatment most likely to be effective beyond 12 months could not be identified from the limited amount of evidence available at this time point. The lack of trials available was a limiting factor of this network meta-analysis, exemplified by the lack of studies reporting data on micronized dehydrated human amniotic/chorionic membrane beyond 2 months. Further trials are needed to provide a better estimate of the most effective injectable treatment for this condition at all time points.
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