54 patients scheduled for anterior cruciate ligament (ACL) reconstruction with a quadruple-stranded semitendinosus tendon autograft were randomized to have the graft augmented with platelet-rich fibrin matrix (PRFM) membranes, or to a control group with no PRFM augmentation. Patients were followed-up on standard and contrast-enhanced MRI over a 12-month period, graft signal intensity was used to measure graft healing, and cross-sectional area was used to measure graft thickness. Results demonstrated no significant differences between groups in either measure at any time point