40 patients with moderate knee osteoarthritis and with clinical symptoms of pain were randomized to receive either MM-II injection, a phosphatidylcholine liposome construct, or a hyaluronic acid injection. The purpose was to compare the safety and efficacy of these two treatments. Outcomes of interest included VAS pain, WOMAC scores, knee range of motion, overall patient satisfaction, and complications. With possible efficacy in pain relief and reducing the need for acetaminophen, additional studies are needed investigating the use of MM-II injection in knee osteoarthritis.