35 patients with osteoarthritis of the knee were randomized to receive either ketorolac injection therapy or corticosteroid injection therapy. The purpose of this study was to determine if ultrasound-guided ketorolac injection demonstrated comparable improvement in knee pain and function after 24 weeks post-injection compared to corticosteroid. Results demonstrated that patients in both study groups had significantly improved pain and function scores from respective baseline measurements, indicating that ketorolac injection therapy may be a viable cost-efficient alternative injection therapy for knee OA.