50 patients scheduled for simultaneous bilateral total knee arthroplasty were randomized to one knee administered an adductor canal block, and the other knee administered a femoral nerve block. Patients were assessed at 6, 12, 24, 48, and 72 hours postoperatively for pain, the straight leg raise test, motor grade, and range of motion, as well as at 1-week follow-up for isometric quadriceps strength. Results demonstrated no significant differences between groups in pain score. The ACB was associated with better results on the SLR for the first 48 hours after surgery compared to the FNB. At 1 week, no significant difference between groups was noted in isometric quadriceps strength.