192 patients with symptomatic, unilateral degenerative knee pathology were randomized to intraarticular injections of either leukocyte-rich platelet-rich plasma or high-molecular-weight hyaluronic acid. Injections were administered once weekly for 3 weeks. Outcomes reported included clinical scores and the incidence of need for re-intervention at the index knee over a 24-month follow-up. Clinical scores were similar between groups, with both groups demonstrating significant improvements in IKDC within 12 months. The PRP group demonstrated a significantly lower rate of required re-intervention when compared to the HA group.