100 patients scheduled for a lumbar fusion surgery were randomized to receive preemptive analgesia with a combination of paracetamol, ketorolac and pregabalin, or no preemptive analgesia. The primary outcomes of interest included pain levels, opioid consumption, patient satisfaction and length of stay. The results from this study found significantly favourable pain levels in the preemptive analgesia group at 4, 8, 12 and 36 hours, as well as pain levels at rest at 48 hours, and pain levels during ambulation at day 1 and 2 compared to the control group. Furthermore, significantly lower opioid consumption, shorter length of hospital stay, and higher patient satisfaction was observed in the preemptive analgesia group.