Seven randomized controlled trials were included in this meta-analysis which compared the efficacy and safety events between low molecular weight heparin and control for thromboprophylaxis in knee arthroscopy. Among pooled efficacy analyses, the only significant difference observed was a lower incidence of asymptomatic deep vein thrombosis among those administered LMWH; incidence of symptomatic venous thromboembolism did not significantly differ between LMWH and control. The incidence of minor bleeding events was significantly higher in LMWH groups, but no significant difference in the incidence of major bleeding events was observed.