70 patients scheduled for total knee arthroplasty and were managed with multimodal analgesia consisting of a continuous adductor canal block, single shot lateral femoral cutaneous nerve block, and posterior infiltration were randomized to either additional dexmedetomidine or epinephrine to a solution of ropivacaine, morphine, and ketorolac. The purpose of this study was to determine if there was a significant difference in time to first rescue analgesia request between groups. Results demonstrated no significant difference between groups in time to first rescue analgesia request, or in mean pain scores or opioid consumption over the first 24 hours after surgery.