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Previous Ace Report COA/ICORS2019: Adjuvant microfracture does not improve outcomes of arthroscopic rotator cuff repair Next Ace Report COA/ICORS2019: Lower pain, similar opioid consumption and mobility with pre-hip op FNB vs usual care
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General Orthopaedics
COA/ICORS2019: NSAID use >4wks, especially indomethacin, associated with non-union in bone fractures
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General Orthopaedics
COA/ICORS2019: NSAID use >4wks, especially indomethacin, associated with non-union in bone fractures
Contributing Authors

H Al Farii L Farahdel A Salimi

6 RCTs (609 patients) were included in this meta-analysis which examined the risk of nonunion after fracture in patients taking non-steroidal anti-inflammatory drugs (NSAIDs). The primary outcome of interest was nonunion, and the relative risk based on duration of use and type of NSAID was analyzed via a regression analysis. The results revealed that NSAID use longer than 4 weeks resulted in a significant increase in risk of nonunion, while NSAID use less than 2 weeks did not display any significant risk of nonunion. Furthermore, indomethacin was found to be associated with a significant risk of nonunion compared to other types of NSAIDs, which did not display any significant risk of nonunion.

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OrthoEvidence. COA/ICORS2019: NSAID use >4wks, especially indomethacin, associated with non-union in bone fractures. ACE Report. 2019;9(6):28. Available from: https://myorthoevidence.com/AceReport/Report/coa-icors2019-nsaid-use-4wks-especially-indomethacin-associated-with-non-union-in-bone-fractures

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