6 randomized controlled trials, including a total of 833 patients, were analyzed to evaluate the efficacy of combined parathyroid hormone (PTH) and alendronate administration in the treatment of osteoporosis. The meta-analysis assessed mean percent increases in bone mineral density (BMD) at the lumbar spine, femoral neck, total hip, and distal radius with combination therapy compared to monotherapy of PTH or teriparatide alone. Results demonstrated no significant differences between combined and monotherapy groups for percent changes in BMD of the lumbar spine, femoral neck, or total hip. Distal radius BMD was observed to significantly increase with combined therapy versus monotherapy.