23 patients diagnosed with patellar tendinopathy were randomized to treatment with eccentric exercise and either ultrasound-guided leukocyte-rich platelet-rich plasma (PRP) injection with dry needling (DN) or dry needling without PRP injection. The purpose of this trial was to compare patient-reported outcomes between to the interventions. Results at 12 weeks revealed statistically and clinically significant improvements in Victorian Institute of Sports Assessment (VISA), Lysholm, and VAS scores versus baseline with PRP whereas only Lysholm scores improved with DN. At 26 weeks, VISA, Tegner, Lysholm and VAS scores improved significantly versus baseline with DN whereas this occurred with only VISA and VAS scores in PRP patients. Nevertheless, overall outcome was not significantly different between groups.