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Early vs standard zoledronic acid treatments for prostate cancer metastatic to bone
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Early vs standard zoledronic acid treatments for prostate cancer metastatic to bone
J Clin Oncol. 2014 Apr 10;32(11):1143-50. doi: 10.1200/JCO.2013.51.6500.
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MR Smith S Halabi CJ Ryan A Hussain N Vogelzang W Stadler RJ Hauke JP Monk P Saylor N Bhoopalam F Saad B Sanford WK Kelly M Morris EJ Small

Six hundred and forty-five patients with castration-resistant prostate cancer and bone metastases were randomized to either early administration of zoledronic acid or standard administration of zoledronic acid initiated following progression to castration-sensitive disease. The purpose was to determine whether early treatment would reduce time to developing a skeletal-related event (SREs) compared to standard treatment. Results indicated similar median time to first SRE, median time to PFS, overall survival, and incidence of adverse events.

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OrthoEvidence. Early vs standard zoledronic acid treatments for prostate cancer metastatic to bone. ACE Report. 2020;10(8):15. Available from: https://myorthoevidence.com/AceReport/Report/early-vs-standard-zoledronic-acid-treatments-for-prostate-cancer-metastatic-to-bone

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