208 patients with knee osteoarthritis were randomized to a combined intervention which consisted of three sessions of patellar mobilization and daily home-based nonloaded vastus medialis oblique exercise over 6 months, or to wait-list control for 6 months. Patients were assessed for outcomes related to change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores, VAS pain score, functional performance tests, and pain-free knee range of motion. Results after 6 months demonstrated significantly greater improvement in all measures in the intervention group compared to the control group.