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Previous Ace Report De Quervain tenosynovitis: higher success rates with corticosteroid injection & thumb cast Next Ace Report De Quervain tenosynovitis: higher success rates with corticosteroid injection & thumb cast
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Arthroplasty
Intraosseous administration of low-dose vanomycin leads to higher tissue concentrations
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Arthroplasty
Intraosseous administration of low-dose vanomycin leads to higher tissue concentrations
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This report has been verified by one or more authors of the original publication.
Clin Orthop Relat Res. 2014 Jan;472(1):57-65. doi: 10.1007/s11999-013-3038-z
Contributing Authors

SW Young M Zhang JT Freeman J Mutu-Grigg P Pavlou GA Moore

32 patients scheduled for total knee arthroplasty were randomized to received three different prophylactic antibiotic regimens: intraosseous administration of either 250mg or 500mg vanomycin, or 1g vanomycin administered intravenously. The purpose was to evaluate the effect of intraosseously administered vanomycin in terms of concentrations in subcutaneous fat, cancellous bone, and systemic blood samples. Intraoperative concentrations of vanomycin in tissue samples were significantly higher with either dose of intraosseous vanomycin compared to intravenous administration.

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OrthoEvidence. Intraosseous administration of low-dose vanomycin leads to higher tissue concentrations. ACE Report. 2014;4(4):42. Available from: https://myorthoevidence.com/AceReport/Report/intraosseous-administration-of-low-dose-vanomycin-leads-to-higher-tissue-concentrations

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