40 patients scheduled for total knee arthroplasty were randomized to either receive or not receive platelet-rich plasma application during surgery. Patients were assessed for hemoglobin and hematocrit levels over the first 48 hours after surgery, and functional and pain outcomes over the first 2 months after surgery. Results demonstrated no significant differences in Hb level, Hct level, knee range of motion, or scores on the Western Ontario and McMaster Universities Osteoarthritis Index between groups. Pain scores were reported to be significantly lower in the PRP group compared to the control group at all time points over the first 2 months postoperatively.