29 out of 40 patients with osteoarthritis of the knee exhibited impaired conditioned pain modulation (CPM) and were randomized to one of two interventions (with cross-over thereafter) for the purpose of examining physiotherapeutic effects on knee pain, pressure pain thresholds, and vibration perception thresholds: (1) oscillatory joint mobilization or (2) cutaneous input (control -light placement of both hands on the subject's knee). Results demonstrated that patients allocated to the joint mobilization group showed significantly decreased pain at rest, pressure pain thresholds, and vibration perception thresholds immediately post-intervention when compared to the cutaneous input group.