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Previous Ace Report Reduced morphine consumption 6hr post-TKA, no 1yr function difference with vs. without suction drain Next Ace Report No significant effect of topical FS or TXA on blood loss in cases of sub-capital femoral fracture
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Arthroplasty
Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication
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Arthroplasty
Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication
Int J Surg. 2019 May;65:45-51.
Contributing Authors

H Li Y Wen W Li Y Yang Y Liu Y Tang

151 patients scheduled for a primary unilateral TKA for osteoarthritis or rheumatoid arthritis were randomized to receive a single 2g dose of oral TXA (2 hrs pre-operation), two doses of oral TXA (2 hrs pre-op, 4 hrs post-op) or multiple doses of oral TXA (2 hrs pre-op, 4, 10 16 hrs post-op). The primary outcome of interest was total blood loss. Results revealed significantly lower amounts of total blood loss in the multi-dose group compared to the single-dose and two-dose groups.

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OrthoEvidence. Multi-dose oral TXA in total knee arthroplasty reduces blood loss with no increase in complication. ACE Report. 2019;9(6):12. Available from: https://myorthoevidence.com/AceReport/Report/multi-dose-oral-txa-in-total-knee-arthroplasty-reduces-blood-loss-with-no-increase-in-complication

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