
Trauma
Nadroparin or fondaparinux for thromboprophylaxis after ankle/foot fracture managed conservatively
This report has been verified
by one or more authors of the
original publication.
Injury. 2017 Apr;48(4):936-940
467 patients managed with a below-knee plaster cast for a foot or ankle fracture were randomized to either subcutaneous nadroparin 2850IE daily, subcutaneous fondaparinux 2.5mg daily, or no thromboprophylaxis intervention (control). Patients were screened during follow-up for cases of deep vein thrombosis and pulmonary embolism. Results demonstrated significantly lower rates of deep vein thrombosis in both the nadroparin and fondaparinux groups compared to the control group. All but two cases of DVT in the control group were asymptomatic; symptomatic patients had pulmonary embolism confirmed by CT angiography.
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