80 patients scheduled for total knee arthroplasty were randomized to periarticular infiltration analgesia completed using either liposomal bupivacaine or plain bupivacaine. Outcomes of interest included pain scores during physical therapy, narcotic consumption, and knee range of motion. Assessment timepoints included 24 hours, 48 hours, 72 hours, and at discharge. While pain scores during physical therapy were significantly lower in the liposomal bupivacaine group at 24 hours after surgery, the differences between groups at 48 hours after surgery and all other outcome measures were not statistically significant.