498 patients scheduled for total knee arthroplasty were randomized to either intraoperative fibrin sealant application or to no additional fibrin sealant. Patients were assessed for the primary outcome of change in knee extension angle after 2 weeks. Among secondary outcomes included the change in knee flexion angle, length of hospital stay, and incidence of complications. Results demonstrated no significant difference between the fibrin sealant and control group for either improvement in knee extension angle, improvement in knee flexion angle, length of hospital stay, or incidence of complications.