Trauma
Saline solution reduces reoperation compared to soap in irrigation of open fractures
This report has been verified
by one or more authors of the
original publication.
N Engl J Med. 2015 Dec 31;373(27):2629-41
2551 patients with an open fracture of the extremity were included in this randomized, 2 by 3 factorial design trial to investigate the effects of irrigation pressure and solution on reoperation rates. The patients were randomized to receive irrigation with either soap or saline at high, low, or very low pressure. After a 12 month follow-up period, the results indicated that the use of saline was superior to the use of soap for the irrigation of open fractures. Additionally, there were no differences between the different pressures, establishing very low pressure as a low-cost alternative in the irrigation of open fractures. The analysis indicated that there was no interaction between irrigation solution and pressure.
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