General Orthopaedics
KAI-1678 no more effective than placebo in acute post-operative pain management
.2013....90 patients scheduled to undergo a total knee or hip arthroplasty were randomized to one of three groups to evaluate the efficacy and safety of a new drug, KAI-1678, in the management of acute post-operative pain. Patients were randomized (in a 2:2:1 fashion) to receive infusions of either KAI-1678, ketorolac or placebo. Results indicated that, although generally well-tolerated, KAI-1678 was no more effective than the placebo in the reduction of pain. Ketorolac, however, displayed significant analgesic effectiveness in these patients.
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