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Efficacy and safety of rhBMP-2 compared to iliac crest bone graft in spinal fusion
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Efficacy and safety of rhBMP-2 compared to iliac crest bone graft in spinal fusion
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Ann Intern Med. 2013 Jun 18;158(12):877-89. doi: 10.7326/0003-4819-158-12-201306180-00005
Contributing Authors

MC Simmonds JV Brown MK Heirs JP Higgins RJ Mannion MA Rodgers LA Stewart

This review/meta-analysis comprised of individual participant data from 11 Medtronic trials and 1 randomized trial, and aggregate data extracted from 35 observational studies, to investigate the efficacy of recombinant human bone morphogenetic protein 2 (rhBMP-2) compared to iliac crest bone grafts in spinal fusion. An analysis of results revealed that fusion rates were higher with rhBMP-2, but did not lead to clinically significant reductions in pain. Safety trends depicted an increased risk of adverse events with rhBMP-2, although these findings were inconclusive.

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OrthoEvidence. Efficacy and safety of rhBMP-2 compared to iliac crest bone graft in spinal fusion. ACE Report. 2013;3(9):9. Available from: https://myorthoevidence.com/AceReport/Report/

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