162 patients scheduled to undergo unilateral total knee arthroplasty were randomized to receive either sciatic and femoral nerve block, or periarticular injection for total knee arthroplasty pain management. This was done to compare the analgesic effect and quadriceps function. Outcomes were measured using tools including a linear analog pain scale and patient-reported adverse events. Results indicated similar pain management between groups, although fewer patients who had received periarticular injections experienced adverse reactions to treatment. Patients in the periarticular group also had shorter lengths of stay, but greater use of narcotics on the day of surgery.