Sixty patients (61 knees) undergoing unicondylar knee arthroplasty were randomized to receive cold compressive dressings (Cryo/Cuff), epidural anesthesia (EDA), or a control treatment using only traditional analgesics as needed. Over 6 weeks, there was no difference between the three groups for pain, bleeding, swelling, and range of motion. However, significantly less morphine was consumed by the Cryo and EDA groups than the control group over the first 24 hours after surgery. There was no difference in morphine consumption between the Cryo and EDA groups.