55 patients scheduled for an Oxford unicompartmental knee arthroplasty were randomized to either patient-specific instrumentation use or conventional instrumentation use for surgery. Patients were assessed for radiographic outcome at 6 weeks postoperatively, while clinical outcome on the Oxford Knee Score was assessed at 12 months postoperatively. Results demonstrated no significant differences between groups in the incidence of tibial or femoral outlying components in either coronal or sagittal alignment. OKS scores also did not significantly differ between groups at 12 months.