30 patients with carpal tunnel syndrome were randomized to undergo single- or two-incision carpal tunnel release to compare clinical and functional outcomes between surgical techniques. Upon analysis, results revealed no significant difference between groups with respect to the Disabilities of the Arm, Shoulder, and Hand (DASH) Questionnaire, Brigham and Womens Carpal Tunnel Questionnaire (BWCTQ) for symptom severity and functional status, grip strength, pinch strength, scar tenderness, or radial and ulnar pillar pain. The single-incision group demonstrated improved Semmes-Weinstein monofilament scores in the second finger at 6 weeks and third finger at 6+ months postoperatively when compared to the two-incision group.